PEGA resins consist of dimethyl acrylamide and mono-2-acrylamidoprop-1-yl[2-aminoprop-1-yl] polyethylene glycol cross-linked with bis 2-acrylamidoprop-1-yl polyethyleneglycol. These supports swell extensively in a wide range of solvents and are permeable to macromolecules up to 35 kD, making them ideal for the preparation of combinatorial libraries, affinity purification and on-resin enzyme assays. For applications of these resins in SPPS and SPOS see [1-18].Note: PEGA resins are supplied swollen in ethanol, with 1g dry resin corresponding to approximately 15 mL of swollen resin. As the beads of PEGA resins become very sticky and easily damaged when shrunk or dried, they are best handled in a swollen state. To use, the appropriate amount of swollen resin should be weighed into a reaction vessel and any residual ethanol removed by copious washings with the appropriate solvent or solvent mixture. After peptide assembly, the resin should be washed with DCM and transferred to the cleavage